Acute Effects of Isoenergetic HIIE Vs. MICE on Key Parameters of Fat Mass Loss in Young Females with Overweight or Obesity (COMEFIT)

Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques

Status: Enrolling

Conditions: High Intensity Interval Exercise (HIIE); Overweight and Obese Adults

Treatments: Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06868862

CAAE: 79561024.4.0000.9487

Details and patient eligibility

About

Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases. Managing obesity effectively requires lifestyle and dietary modifications, including increased physical activity. Among the various exercise strategies, Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) are widely recommended for reducing FM. Compared to MICT, HIIT is a time-efficient approach, often perceived as more enjoyable, and has been shown to promote greater total and abdominal fat loss in a shorter period. However, the precise mechanisms underlying this enhanced fat loss remain unclear.

This study aims to compare the acute effects of two isoenergetic exercise sessions - MICE (Moderate-Intensity Continuous Exercise) and HIIE (High-Intensity Interval Exercise) - on key physiological responses involved in fat mass loss. Specifically, we will assess plasma catecholamine levels during exercise and recovery, as well as oxygen consumption, substrate oxidation, and appetite over the 2-hour post-exercise period in young females with overweight or obesity. By elucidating the role of catecholaminergic stimulation as a potential regulator of fat mass loss, this research could provide valuable insights for optimizing exercise strategies in weight management and metabolic health.

Enrollment: 15 estimated patients

Sex: Female

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women with overwieght or obesity (BMI: 25-35 kg/m²)

Exclusion criteria

• contraceptive use
• menopause
• irregular menstrual cycle
• medical contraindications to intense physical activity,
• painful joints,
• taking ß-blocker

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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15 participants in 2 patient groups

High Intensity Interval Exercise

Experimental group

Description:

High Intensity Interval Exercise: 5 minutes of WarmUp + 10 x (1 minute at 85% HRmax followed by 1 minute of recovery at a power equivalent to 40% of HRmax)

Treatment:

Other: Exercise

Moderate Intensity Continuous Exercise

Experimental group

Description:

Moderate Intensity Continuous Exercise: 5 minutes of WarmUp + 35 minutes at 55% HRmax

Treatment:

Other: Exercise