Acute Effects of LBBP Versus BVP for CRT

Fudan University

Status: Completed

Conditions: Cardiac Pacing, Artificial; Cardiac Resynchronization Therapy; Heart Failure

Treatments: Procedure: biventricular pacing; Procedure: left bundle branch pacing

Study type: Interventional

Funder types: Other

Identifiers

NCT04505384

ZS-LBBPvsBVP

Details and patient eligibility

About

The study was designed to compare the acute effects of left bundle branch pacing (LBBP) with biventricular pacing (BVP) in patients with left ventricular ejection fraction (LVEF) <=35% with left bundle branch block (LBBB).

Full description

The metrics include electrocardiographic, echocardiographic and hemodynamic parameters to evaluate and compare LBBP with BVP for resynchronization therapy in patients with heart failure and LBBB.

Enrollment: 25 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• NYHA class II-IV;
• LVEF <=35%;
• LBBB with QRS duration >=130ms.

Exclusion criteria

• moderate-to-severe aortic stenosis;
• frequent premature ventricular complexes;
• significant peripheral vascular disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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25 participants in 2 patient groups

Left bundle branch pacing

Experimental group

Description:

Left bundle branch pacing

Treatment:

Procedure: left bundle branch pacing

Biventricular pacing

Active Comparator group

Description:

Biventricular pacing

Treatment:

Procedure: biventricular pacing