Acute Effects of Natural and Interesterified Fats-margarine on Lipemic and Insulinemic Response

Malaysia Palm Oil Board

Status: Completed

Conditions: Healthy

Treatments: Other: Trans free palm margarine; Other: IE Soybean oil-based margarine; Other: Interesterified Palm based margarine

Study type: Interventional

Funder types: Other

Identifiers

NCT02194673

AH 00112

Details and patient eligibility

About

Interesterified (IE) fat blends will respond differently in terms of postprandial lipemia and insulinemic responses compare to a trans free palm margarine (TFPM).

Full description

The objective of this study was to investigate whether IE-fat blends behave differently on postprandial serum lipid, insulin, C-peptide and glucose concentration compare to TFPM. A randomised, double-blind crossover (3 × 3 arms) orthogonal Latin-square design was used and conducted on 10 males and 10 females adults. During postprandial challenge day, each subject received an a test muffin incorporated with test margarine. Blood samples were collected at half-hourly intervals until 4 hr by using cannulation technique.

Enrollment: 20 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body Mass Index (BMI) between 18.5 and 24.9
• <130mmHg for systolic pressure and <80 mmHg for diastolic pressure
• Blood glucose level in the range of 3.9 to 5.5 mmol/L
• Total cholesterol less than 5.17 mmol/L
• No use of tobacco and no consumption of alcohol.

Exclusion criteria

• Suffer from chronic disease
• Metabolic syndrome
• Consuming any medical prescriptions
• People with blood clotting problem
• Women who are pregnant
• Hypertensive person

Trial design

20 participants in 3 patient groups

Trans free palm margarine

Experimental group

Description:

One high fat muffin will be serves together with a glass of low fat milk shake.

Treatment:

Other: Interesterified Palm based margarine

Other: IE Soybean oil-based margarine

Other: Trans free palm margarine

Interesterified palm based margarine

Experimental group

Description:

One high fat muffin will be serves together with a glass of low fat milk shake.

Treatment:

Other: Interesterified Palm based margarine

Other: IE Soybean oil-based margarine

Other: Trans free palm margarine

IE soybean oil-based margarine

Experimental group

Description:

One high fat muffin will be serves together with a glass of low fat milk shake.

Treatment:

Other: Interesterified Palm based margarine

Other: IE Soybean oil-based margarine

Other: Trans free palm margarine