Acute Effects of Nutrition Supplementation on Treatment Efficiency and Hemodynamics During Dialysis

University of Illinois at Urbana-Champaign

Status: Completed

Conditions: Dietary Modification; Blood Pressure; Kidney Failure, Chronic

Treatments: Dietary Supplement: Nepro

Study type: Interventional

Funder types: Other

Identifiers

NCT02371018

14385

Details and patient eligibility

About

The purpose of this study is to examine the effect of nutritional supplementation during hemodialysis treatment on beat-to-beat hemodynamics and treatment efficiency in a crossover design.

Full description

The consumption of food or nutritional supplements during hemodialysis treatment has been shown to improve nutritional status, improve quality of life, and reduce mortality.

Despite these observations, allowing patients to eat food during hemodialysis treatment is sometimes restricted in the United States. The reasons for this restrictive policy are multi-factorial, but include concerns related to drops in blood pressure BP or a reduced efficiency of solute removal following eating during HD treatment. An alternative to eating solid food is to provide patients with liquid nutritional supplements. Clinics in the US are more likely to allow the consumption of liquid nutritional supplements, however, little is known about the effect that liquid supplements have on blood pressure or treatment efficiency. Therefore, the investigators plan to examine the effect of nutritional supplementation during hemodialysis treatment on hemodynamics and treatment efficiency in a crossover design.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Receiving hemodialysis treatment three times per week, on hemodialysis for greater than three months, receive medical clearance from a Nephrologists

Exclusion criteria

• Milk or soy allergy, more than 4 hypotensive events requiring intervention in the last two weeks, hospitalized due to hypotension in the previous week

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 3 patient groups

Standard Hemodialysis

No Intervention group

Description:

Participants will be monitored during their normal hemodialysis treatment with no intervention administered

Hemodialysis with Nutrition Supplement

Experimental group

Description:

Participants will be monitored during a normal hemodialysis treatment in which they consume 1-8oz can of Nepro.

Treatment:

Dietary Supplement: Nepro

Nutrition Supplement

Experimental group

Description:

Participants will be monitored while drinking 1-8oz can of Nepro with no hemodialysis treatment.

Treatment:

Dietary Supplement: Nepro