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Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.

N

National Institute of Cardiology, Laranjeiras, Brazil

Status

Completed

Conditions

Metabolic Syndrome

Treatments

Other: sugar and fat oral load
Other: fat oral load
Other: sugar oral load

Study type

Interventional

Funder types

Other

Identifiers

NCT03515460
CAAE 86854318.8.0000.5272

Details and patient eligibility

About

The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.

Full description

The chronic and elevated consumption of fat and carbohydrates is associated with the initiation and the progression of cardiovascular and metabolic diseases, including diabetes, obesity and metabolic syndrome. In general, chronic diseases are related to underlying modifiable cardiovascular risk factors, including high blood pressure, high plasma lipids and glucose, physical inactivity, overweight and obesity, as well as smoking habits.

Vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. Moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease.

Thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.

Enrollment

60 patients

Sex

All

Ages

20 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy individuals presenting body mass index between 18.5 e 24.9 kg/m2

Exclusion criteria

  • dysglycemia and dyslipidemia
  • overweight and obesity

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

60 participants in 3 patient groups

sugar oral load
Experimental group
Description:
oral ingestion of a high carbohydrate meal
Treatment:
Other: sugar oral load
fat oral load
Experimental group
Description:
oral ingestion of a high fat meal
Treatment:
Other: fat oral load
sugar and fat oral loads
Experimental group
Description:
oral ingestion of a high carbohydrate and fat meal
Treatment:
Other: sugar and fat oral load

Trial contacts and locations

1

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Central trial contact

Eduardo TIBIRICA, MD, Phd; Andrea Lorenzo, MD, PhD

Data sourced from clinicaltrials.gov

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