Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.

National Institute of Cardiology, Laranjeiras, Brazil

Status: Completed

Conditions: Metabolic Syndrome

Treatments: Other: sugar and fat oral load; Other: fat oral load; Other: sugar oral load

Study type: Interventional

Funder types: Other

Identifiers

NCT03515460

CAAE 86854318.8.0000.5272

Details and patient eligibility

About

The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.

Full description

The chronic and elevated consumption of fat and carbohydrates is associated with the initiation and the progression of cardiovascular and metabolic diseases, including diabetes, obesity and metabolic syndrome. In general, chronic diseases are related to underlying modifiable cardiovascular risk factors, including high blood pressure, high plasma lipids and glucose, physical inactivity, overweight and obesity, as well as smoking habits.

Vascular endothelial dysfunction is one of the earliest findings in the pathophysiology of atherosclerosis and also an important predictor of cardiovascular events. Moreover, it has already been demonstrated that acute oral ingestion of high loads of sugar and fat meals induces transient vascular endothelial dysfunction, which over time could lead to cardiovascular disease.

Thus, the present study aimed at investigating the individual contributions of sugar and fat ingestion on systemic microvascular endothelial reactivity.

Enrollment: 60 patients

Sex: All

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals presenting body mass index between 18.5 e 24.9 kg/m2

Exclusion criteria

• dysglycemia and dyslipidemia
• overweight and obesity

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

sugar oral load

Experimental group

Description:

oral ingestion of a high carbohydrate meal

Treatment:

Other: sugar oral load

fat oral load

Experimental group

Description:

oral ingestion of a high fat meal

Treatment:

Other: fat oral load

sugar and fat oral loads

Experimental group

Description:

oral ingestion of a high carbohydrate and fat meal

Treatment:

Other: sugar and fat oral load