Acute Effects of Smoking on Airway Dendritic Cells

University of Rostock

Status: Completed

Conditions: Tobacco Use Disorder

Treatments: Behavioral: Smoking

Study type: Interventional

Funder types: Other

Identifiers

NCT00740896

LO-2222

Details and patient eligibility

About

Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway dendritic cells.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Active smoking (at least 10 cigarettes per day)
• Age > 18 years

Exclusion criteria

• Any chronic diseases
• Any regular medication
• Any signs or symptoms of an acute infection

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 2 patient groups

1

Active Comparator group

Description:

Participants smoke 8 cigarettes in 4 hours.

Treatment:

Behavioral: Smoking

Behavioral: Smoking

2

Sham Comparator group

Description:

Participants are not allowed to smoke for 4 hours.

Treatment:

Behavioral: Smoking

Behavioral: Smoking