Acute Effects of Spirulina on Postprandial Glycemic Responses and Arterial Blood Pressure

Agricultural University of Athens

Status: Completed

Conditions: Appetitive Behavior; Potential Abnormality of Glucose Tolerance; Blood Pressure

Treatments: Other: Beverage containing 6g spirulina; Other: Beverage containing 8g spirulina; Other: Glucose as reference food; Other: Beverage containing 4g spirulina

Study type: Interventional

Funder types: Other

Identifiers

NCT05484336

HRBD 54 06/06/2022

Details and patient eligibility

About

This study investigated the effects of three doses of spirulina in glucose beverages on postprandial glycemic responses, arterial blood pressure, and subjective satiety.

Full description

This study aimed to determine the effects of three different doses (4, 6 and 8 g) of spirulina in glucose beverages on postprandial glycemic responses, blood pressure, and subjective appetite responses in healthy young adults.

Enrollment: 13 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy
• non-smokers
• men and women
• body mass index between 18 and 24.9 kg/m2
• normal blood pressure (systolic blood pressure <120 mmHg and diastolic blood pressure <80 mmHg)
• normal fasting blood glucose concentrations (<100 mg/dL)

Exclusion criteria

• Medical conditions (e.g., cardiovascular diseases, diabetes mellitus, kidney or liver conditions, severe clinical depression, gastrointestinal disorders)
• Under medications known to affect glycemia (glucocorticoids, metformin, thiazide diuretics)
• Allergy to spirulina
• Pregnancy
• Lactation
• Competitive sports
• Alcohol abuse
• Drug dependency

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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13 participants in 4 patient groups

Glucose as reference food

Experimental group

Description:

Thirteen healthy young adults, with BMI between 18 and 29.9 kg/m2 (male: 3, female:10) after 10-14h fast, consumed 50 g available carbohydrates from D-glucose, two times, in different weeks as reference food along with 300 mL water; and 50 g available carbohydrates from beverages containing 4, 6 and 8 g spirulina, tested once, in different visits, along with 300 mL water. There was a washout period of at least two days between visits. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120min postmeal. The first glucose sample was taken exactly 15min after the beginning of the consumption of the tested food.

Treatment:

Other: Beverage containing 8g spirulina

Other: Beverage containing 6g spirulina

Other: Beverage containing 4g spirulina

Other: Glucose as reference food

Glucose beverage containing 4 g spirulina

Experimental group

Description:

Thirteen healthy young adults, with BMI between 18 and 29.9 kg/m2 (male: 3, female:10) after 10-14h fast, consumed 50 g available carbohydrates from D-glucose, two times, in different weeks as reference food along with 300 mL water; and 50 g available carbohydrates from beverages containing 4, 6 and 8 g spirulina, tested once, in different visits, along with 300 mL water. There was a washout period of at least two days between visits. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120min postmeal. The first glucose sample was taken exactly 15min after the beginning of the consumption of the tested food.

Treatment:

Other: Beverage containing 8g spirulina

Other: Beverage containing 6g spirulina

Other: Beverage containing 4g spirulina

Other: Glucose as reference food

Glucose beverage containing 6 g spirulina

Experimental group

Description:

Thirteen healthy young adults, with BMI between 18 and 29.9 kg/m2 (male: 3, female:10) after 10-14h fast, consumed 50 g available carbohydrates from D-glucose, two times, in different weeks as reference food along with 300 mL water; and 50 g available carbohydrates from beverages containing 4, 6 and 8 g spirulina, tested once, in different visits, along with 300 mL water. There was a washout period of at least two days between visits. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120min postmeal. The first glucose sample was taken exactly 15min after the beginning of the consumption of the tested food.

Treatment:

Other: Beverage containing 8g spirulina

Other: Beverage containing 6g spirulina

Other: Beverage containing 4g spirulina

Other: Glucose as reference food

Glucose beverage containing 8 g spirulina

Experimental group

Description:

Thirteen healthy young adults, with BMI between 18 and 29.9 kg/m2 (male: 3, female:10) after 10-14h fast, consumed 50 g available carbohydrates from D-glucose, two times, in different weeks as reference food along with 300 mL water; and 50 g available carbohydrates from beverages containing 4, 6 and 8 g spirulina, tested once, in different visits, along with 300 mL water. There was a washout period of at least two days between visits. Fingertip capillary blood glucose samples were taken at 0, 15, 30, 45, 60, 90 and 120min postmeal. The first glucose sample was taken exactly 15min after the beginning of the consumption of the tested food.

Treatment:

Other: Beverage containing 8g spirulina

Other: Beverage containing 6g spirulina

Other: Beverage containing 4g spirulina

Other: Glucose as reference food