Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers

Inogen

Status: Completed

Conditions: Cognition

Treatments: Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air

Study type: Interventional

Funder types: Industry

Identifiers

NCT06555484

INO-06

Details and patient eligibility

About

Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory tests.

Full description

Prior studies have reported that supplemental oxygen can confer acute benefits to cognition. Here, the investigators seek to replicate/extend such findings by assessing whether such benefits can be seen using an Inogen oxygen concentrator with subjects with an average age around 65 years old. The investigators include a standard measure of cognition previously reported to be sensitive to supplemental oxygen (2-back test) and a novel, in-development adaptation of a memory test for medical-related content (Medical icons spatial test).

Enrollment: 40 patients

Sex: All

Ages: 22 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Subjects are intended to represent "healthy adults." Patients will include a mix of self-reported gender and ethnic/racial identification.

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. Adult (aged 22+)

Exclusion criteria

• Patients who self-report diagnosis of respiratory-related conditions will be excluded.
• Subjects with a known polyvinyl chloride (PVC) allergy will be excluded, due to potential use of a standard, PVC-based cannula in the study.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Air First

Other group

Description:

All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.

Treatment:

Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air

Oxygen First

Other group

Description:

All study participants, completing memory tests while breathing either supplemental oxygen followed by air, or breathing air followed oxygen.

Treatment:

Device: Cross Over Assignment Supplemental Oxygen and Supplemental Air