Acute Effects of TCIG vs ECIG in PLWH

University of California, Los Angeles (UCLA)

Status: Completed

Conditions: E Cigarette Use; Inflammation; Qt Interval, Variation in; Nicotine Use Disorder; Tobacco Smoking; Oxidative Stress; Vaping; Smoking; HIV I Infection

Treatments: Other: sham control; Other: ECIG; Other: TCIG

Study type: Interventional

Funder types: Other

Identifiers

NCT04568395

20-001179

Details and patient eligibility

About

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.

Full description

On separate days, participants will undergo 3 different exposures: an acute e-cigarette exposure, an acute tobacco cigarette exposure, and a sham (empty e-cigarette) control . Before and after the acute exposure, participants will have blood drawn for inflammation/oxidative stress markers and undergo a 5-minute ECG recording.

Enrollment: 37 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Chronic (> 1year) TCIG smoker HIV positive Stable ART Viral count non-detectable CD4 >500

Exclusion criteria

Known major illness (heart disease, diabetes, lung or liver disease) Daily recreational drug use, including cannabis >2 alcoholic drinks per day Obesity (>30 kg/m2) Recent (<3 months) infection

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 1 patient group

PLWH smoker

Experimental group

Description:

PLWH who smoke will undergo 3 interventions : acute TCIG use, acute ECIG use and acute sham control

Treatment:

Other: TCIG

Other: sham control

Other: ECIG