Acute Exercise and Energy Balance Regulation: Effect of Intensity

University Hospital, Clermont-Ferrand

Status: Unknown

Conditions: Obesity

Treatments: Other: metabolic chamber

Study type: Observational

Funder types: Other

Identifiers

NCT01036360

CHU-0063

Details and patient eligibility

About

Physical activity is mainly considered and use for its impact on energy expenditure in the treatment of obesity, and less is known concerning its indirect effects on energy intake. The aim of this work is to clarify the impact of an acute bout of exercise, depending on its intensity (high versus low), on the following energy intake and nutrient utilization, in obese and non-obese boys and men.

Full description

20 adolescent boys (10 obese and 10 leans) and 20 men (10 obese and 10 lean) will complete a sub-maximal test on a ergo cycle to draw their linear relationship between VO2 and Fc. Then they will enter a metabolic chamber three times, for 24 hours each. A first session will be considered as sedentary, and volunteers will remain inactive. During the second and third session, they will have to complete a cycling test generating an energy expenditure of 400 Kcal, once at low intensity (40%VO2max) and once at high intensity (70% VO2max). Those three sessions will be realized in a randomized order with an interval of at least 7 days and urinary collection over the 24hours will be done during all the sessions. At the beginning of the protocol, blood samples will be taken, body composition assessed by DXA and adiposity location evaluated by MNR.

Enrollment: 40 estimated patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male

• Adults between 18 to 30 years old and adolescents between 12 and 15 years old

• Body mass index :

  • lean adults : 20 <BMI< 25 kg.m²
  • obese adults : 30<BMI<38 kg.m²
  • lean adolescents: BMI <90th percentile
  • obese adolescents: BMI>97th percentile

• Affiliated to National Health Insurance

• Subject giving his written informed consent

• Subject considered as normal after clinical examination and medical questionnaire.

Exclusion criteria

• Chronic pathologies : cardiovascular diseases, cancer, chronic inflammation diseases, renal, intestinal impairments
• Refusal to be registered on the National Volunteers Data file
• Being in exclusion on the National Volunteers Data file
• Practising intensive physical exercise
• Heavy consumer of alcohol or/and tobacco
• Previous medical and/or surgery judged by the investigator as incompatible with this study

Trial design

40 participants in 1 patient group

physical activity

Treatment:

Other: metabolic chamber