Acute Exercise and Microvascular Function

Josip Juraj Strossmayer University of Osijek

Status: Unknown

Conditions: Physical Exertion

Treatments: Other: Acute Exhausting Exercise (AE)

Study type: Interventional

Funder types: Other

Identifiers

NCT02727439

215861071403

Details and patient eligibility

About

It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature. Acute exertional exercise can induce large, transient increases in arterial pressure and development of metabolic acidosis which can be associated with pro-inflammatory response involving oxidant stress and circulating cytokines known to impair endothelial function.

The aim of this study is to test the impact of a single exposure to exhausting training on microvascular reactivity in healthy sedentary subjects and athletes.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy volunteers
• active athletes
• lean sedentary subjects

Exclusion criteria

• drugs that could affect the endothelium
• overweight
• hypertension
• coronary artery disease
• diabetes
• hyperlipidaemia
• renal impairment
• cerebrovascular and peripheral artery disease

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

Sedentary Subjects

Experimental group

Description:

Healthy lean sedentary subjects.

Treatment:

Other: Acute Exhausting Exercise (AE)

Athletes

Experimental group

Description:

Active athletes.

Treatment:

Other: Acute Exhausting Exercise (AE)