Acute Exercise and Pancreatic Endocrine Function

Rigshospitalet

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01812590

Ex-Panc

Details and patient eligibility

About

Subjects with type 2 diabetes will be stratified into two-quantiles based on ambient hyperglycemia (fasting glucose and HbA1c) and then the effects of a single aerobic exercise bout (1-hour at 50%VO2max) on pancreatic endocrine function will be determined.

Enrollment: 14 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previous diagnosis with type 2 diabetes, or newly detected in our screening procedures
• Age 30-70 years
• BMI 20-40 kg/m2

Exclusion criteria

• Treatment with insulin
• Contraindication to exercise as determined by ECG
• Pregnancy
• Active weight loss in the previous 6 months
• Actively engaged in exercise training programs
• Evidence of chronic pulmonary, cardiovascular, hepatic, renal, or hematological disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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14 participants in 2 patient groups

Resting Trial

No Intervention group

Description:

Pancreatic endocrine function will be determined the morning following a day where no exercise is performed

Exercise Trial

Experimental group

Description:

Pancreatic endocrine function will be determined the morning following a day where a 1-hour aerobic exercise is performed at 65% of pre-determined HRmax (maximal heart rate measured during an incremental work-load exercise test to volitional exhaustion)

Treatment:

Behavioral: Exercise