Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD

National Taiwan Normal University

Status: Completed

Conditions: Alzheimer Disease 2 Due to Apoe4 Isoform

Treatments: Behavioral: MI-30; Behavioral: HI-16; Behavioral: LI-40

Study type: Interventional

Funder types: Other

Identifiers

NCT05591313

PACNL_EV_ERP_APOE

Details and patient eligibility

About

This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.

Full description

Acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of Alzheimer's disease (AD) and the role of exercise variance and APOE genotype within the effect reminds underestimated. The current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. Additionally, we determined whether variations in exercise intensity and duration and the presence of the APOE ɛ4 allele modulated the effect.

Enrollment: 51 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adults aged between 50 and 70 years old
2. Normal or corrected-to-normal vision based on the minimal 20/20 standard
3. Cognitively normal as mini-mental state examination scores (MMSE) > 26

Exclusion criteria

1. Neurological or psychiatric disorders
2. Cardiovascular disease
3. Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
4. Red-green color blindness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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51 participants in 4 patient groups

Low-intensity with longer duration (40-min) exercise (LI-40)

Experimental group

Description:

The participants were instructed to complete a volume-matched low-intensity with longer duration (40-min) exercise (LI-40) treatment.

Treatment:

Behavioral: LI-40

Moderate-intensity with 30 min exercise (MI-30)

Experimental group

Description:

The participants were instructed to complete a volume-matched moderate-intensity with 30 min exercise (MI-30) treatment.

Treatment:

Behavioral: MI-30

High-intensity with shorter duration (16-min) exercise (HI-16)

Experimental group

Description:

The participants were instructed to complete a volume-matched high-intensity with shorter duration (16-min) exercise (HI-16) treatment.

Treatment:

Behavioral: HI-16

Control treatment (CON)

No Intervention group

Description:

The participants in the control treatment (CON) were instructed to complete book reading for 30-min.