Acute Health Effects of High Temperature Exposure

Fudan University

Status

Active, not recruiting

Conditions

Cognitive Function

Cardiovascular System

Respiratory System

Treatments

Other: moderate temperature (22℃) group

Other: high temperature (32℃) group

Study type

Interventional

Funder types

Other

Identifiers

NCT05575752

FDUEH-8

Details and patient eligibility

About

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.

Full description

The investigators will conduct a randomized controlled human exposure crossover study among about 30 healthy young adults in Shanghai, China. Each subject will be exposed twice: once to the high temperature (32℃) and once to moderate temperature (22℃) in a chamber for about 2 hours. During the exposure session, each subject will be requested to rest. Health examinations will be conducted immediately prior to exposure, during the period of exposure and after exposure. Health examinations include symptom questionnaire, blood pressure tests, cognitive function tests, magnetic resonance imaging, skin tests, spirometry, and Holter monitoring. Investigators plan to collect blood, urine and oropharyngeal swabs samples.

Enrollment

30 patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Living in Shanghai during the study period;
Body mass index > 18.5 and ≤ 28;
right-handed;
receiving or having received higher education;
with ability to read and understand Chinese smoothly.

Exclusion criteria

Smoking and alcohol abuse;
Current drug and dietary supplements intake;
Subjects with allergic diseases, such as allergic rhinitis, allergic asthma, and atopy;
Subjects with cardiovascular diseases, such as congenital heart disease, pulmonary heart disease, and hypertension;
Subjects with respiratory diseases, such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease;
Subjects with chronic diseases, such as diabetes, chronic hepatitis, and kidney disease;
Subjects who have a history of major surgery due to the cardiovascular, cerebrovascular, respiratory, or neurological diseases;
Subjects with neurologic disorders, such as stroke, traumatic brain injury, epilepsy, and schizophrenia;
Abnormal spirometry (FEV1 and FVC ≤ 75% of predicted and FEV1/FVC ≤ 0.65);
Subjects with color vision disabilities.