Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults

University of British Columbia

Status: Unknown

Conditions: Leukocytosis; Cognitive Function; Inflammatory Response; Triglycerides

Treatments: Dietary Supplement: Black coffee; Dietary Supplement: High-fat coffee

Study type: Interventional

Funder types: Other

Identifiers

NCT04307979

Bulletproof Coffee

H19-02684 (Other Identifier)

Details and patient eligibility

About

This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.

Full description

In a randomized crossover design, participants will consume a single bulletproof coffee or a single black coffee separated by ~7 days. Each visit commences in the morning after an overnight fast of 10-12 hours, with no exercise the day prior, no coffee consumption the morning of testing, and completion of a food log for dietary duplication prior to visit 2. A fasting blood draw is obtained and cognitive function tests administered, along with questionnaires to assess gastrointestinal distress, arousal, and hunger/fullness before coffee consumption. Following this, one of the coffee beverages is consumed (randomized to each visit). Cognitive testing and questionnaires are completed at 60 minutes after finishing the coffee, another blood draw at 90 minutes, and then cognitive testing, questionnaires and a final blood draw 180 minutes after consuming the coffee. This procedure is repeated during their second experimental visit, in which they consume the remaining coffee based on their randomization.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Must be over the age of 18
• Must drink between 1-4 cups of coffee per day (on average)
• Must be able to tolerate lactose and dairy products
• Have not been sick for the past 3 weeks (immune function)
• Non smoker
• Must be able to fast for 10-12 hours

Exclusion criteria

• If you are required to take corticosteroids (immune function)
• Cannot understand or speak English
• Individual has an auto-immune disease and requires medication
• Individual is following a ketogenic diet
• Individual has allergy or sensitivity to dairy, coffee or caffeine or coconut oil
• Individual has hypertension

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

Bulletproof Coffee

Experimental group

Description:

A black coffee (bullet proof coffee keurig pod) with 29 grams of added fat (1 tablespoon bullet proof brain octane medium chain triglyceride oil, and 1 tablespoon bullet proof grass fed ghee) blended for 20 seconds with butter scent that is added to the lid.

Treatment:

Dietary Supplement: High-fat coffee

Dietary Supplement: Black coffee

Black Coffee

Placebo Comparator group

Description:

Black coffee that is blended for 20 seconds with butter scent added to the top of the lid.

Treatment:

Dietary Supplement: High-fat coffee

Dietary Supplement: Black coffee