Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths

Universidade Estadual Paulista Júlio de Mesquita Filho

Status: Completed

Conditions: Coronary Artery Disease; Autonomic Nervous System Disease; Heart Rate; Blood Pressure

Treatments: Other: Protocol Beet; Other: Protocol Resveratrol; Other: Protocol Beet and Resveratrol; Other: Placebo Protocol

Study type: Interventional

Funder types: Other

Identifiers

NCT06095635

UEPJMG

Details and patient eligibility

About

Introduction: Most cardiovascular diseases (CVD) can be prevented and controlled by adopting lifestyle changes, such as regular physical exercise and nutrition. Resveratrol and beverage extract promote beneficial health effects due to their nutritional properties. Objective: to analyze the effects of resveratrol supplementation and withdrawal extract on post-exercise recovery in coronary heart disease patients. Methods: men diagnosed with ischemic coronary artery disease will undergo four exercise protocols consisting of 30 minutes of aerobic exercise on an ergometric treadmill, with 5 minutes of warm-up, intensity of 30% of the heart rate reserve (HRR), followed by 25 minutes at intensity 60% of FCR and for a final 30 minutes of recovery in the supine position. Before each exercise protocol, all volunteers will consume: 500 mg of placebo (starch), or 500 mg of beetroot, or 500 mg of resveratrol and will also consume resveratrol and drink (500 mg each) 30 minutes before exercise. , the order of each supplementation will be done randomly. Cardiorespiratory parameters and heart rate variability (HRV) will be assessed at different times throughout the experimental procedure. To analyze the moments (rest versus recovery), the Bonferroni post-test will be used for parametric distribution or the Dunn post-test for non-parametric distribution. Statistical significance will be calculated at 5% for all analyses.

Enrollment: 17 patients

Sex: Male

Ages: 40 to 79 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult men over 45 years of age
• diagnosed with ischemic coronary artery disease and with preserved left ventricular function (above 50%), confirmed by a previous echocardiogram

Exclusion criteria

Volunteers who present at least one of the following characteristics will be excluded:

• smokers
• alcohol drinkers
• those who did not attend a cardiovascular rehabilitation program for at least 3 months prior to data collection
• individuals who have known infections, metabolic and respiratory diseases that could interfere in cardiac autonomic control, unstable angina, uncontrolled hypertension, significant valvular disease, uncontrolled metabolic disease (e.g., uncontrolled diabetes and thyroid disease)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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17 participants in 4 patient groups, including a placebo group

Placebo Protocol

Placebo Comparator group

Description:

exercise and placebo capsules 500 mg (starch)

Treatment:

Other: Placebo Protocol

Protocol Beet

Experimental group

Description:

exercise and beet extract 500 mg

Treatment:

Other: Protocol Beet

Protocol Resveratrol

Experimental group

Description:

exercise and resveratrol capsules 500 mg

Treatment:

Other: Protocol Resveratrol

Protocol Beet and Resveratrol

Experimental group

Description:

exercise and beet extract 500mg and resveratrol capsules 500 mg

Treatment:

Other: Protocol Beet and Resveratrol