Acute Intermittent Hypoxia in Persons With Multiple Sclerosis

Shirley Ryan AbilityLab

Status: Completed

Conditions: Multiple Sclerosis, Relapsing-Remitting

Treatments: Other: Intermittent Hypoxia; Other: Sham Hypoxia

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT04280484

STU00207024

Details and patient eligibility

About

The overall objective of this project is to investigate the effectiveness of Acute Intermittent Hypoxia (AIH), to improve muscle strength and activity level in individuals with relapsing-remitting MS.

Enrollment: 10 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have relapsing-remitting MS
• Volitional ankle plantar flexion strength in at least one leg
• Are relapse free for 30 days
• Patient-Determined Disease Steps scale score between 3 and 5 (3=gait disability to 5=late cane, need cane to walk 25 feet)

Exclusion criteria

• Currently taking antispasticity medications,
• Have cardiovascular or respiratory/pulmonary disorders, metabolic dysfunction, or prior diagnoses of obstructive sleep apnea
• Pregnant or nursing women (safety for developing fetus or infant is unknown)
• Cognitive concerns (must be able to consent to study, follow steps)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups

Acute Intermittent Hypoxia

Experimental group

Description:

1 minute of 9% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts

Treatment:

Other: Intermittent Hypoxia

Sham Acute Intermittent Hypoxia

Sham Comparator group

Description:

1 minute of 21% oxygen in the inspired air, alternating with 1 minute of 21% oxygen; for a total of 15 bouts.

Treatment:

Other: Sham Hypoxia