Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria

Hospital de Base

Status: Completed

Conditions: Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT00777465

CAAE-3436.0.000.140-08

Details and patient eligibility

About

The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and evaluate its impact as a predictor of 30-day mortality.

Full description

This was a single center study. We evaluated retrospectively patients from the Cardiac Surgery Intensive Care Unit in Hospital de Base, São José do Rio Preto Medical School, São Paulo, Brazil. Demographics, type of surgery, laboratory data and preoperative, perioperative, and postoperative information were retrieved from a prospectively collected database of 2878 patients older than 18 years undergoing isolated CABG (1786) or CVS (1092), from January 2003 to June 2013. After applying the exclusion criteria (51 patients with incomplete data and 23 patients with end-stage kidney disease) we analyzed 2804 patients in total, 1738 (62%) underwent CABG and 1066 (38%) underwent CVS.

Enrollment: 2,804 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients undergoing isolated coronary artery bypass grafting or cardiac valve surgery.

Exclusion criteria

patients with incomplete data and patients with end-stage kidney disease.

Trial design

2,804 participants in 4 patient groups

KDIGO 0

Description:

Patients with no acute kidney injury after cardiac surgery

KDIGO 1

Description:

Patients with acute kidney injury KDIGO stage 1 after cardiac surgery (Increase in SCr by ≥ 0.3 mg/dL (≥ 26.5 lmol/L) or 1.5 to 1.9 times baseline)

KDIGO 2

Description:

Patients with acute kidney injury KDIGO stage 2 after cardiac surgery (2.0 to 2.9 times baseline SCr)

KDIGO 3

Description:

Patients with acute kidney injury KDIGO stage 3 after cardiac surgery (3.0 times baseline or more; or increase in SCr to ≥ 4.0 mg/dL; or initiation of renal replacement therapy)