Acute Kidney Injury in Critical COVID-19: Outcomes and Risks

Ankara University

Status: Completed

Conditions: Mortality; Intensive Care Unit (ICU) Admission; Acute Kidney Injury; COVID -19

Study type: Observational

Funder types: Other

Identifiers

NCT07089693

İ05-257-22

Details and patient eligibility

About

This retrospective observational study aims to determine the incidence of acute kidney injury (AKI) associated with COVID-19, risk factors, and effects on mortality for intensive care unit patients. Data from 238 COVID-19 patients monitored in the Anesthesiology and Reanimation Intensive Care Unit of Ankara University Ibni Sina Hospital between January 1, 2021 and January 1, 2022 were retrospectively reviewed. Patients were divided into two groups according to the level of renal damage (with and without AKI). Those with AKI were staged per the KDIGO criteria (Stage 1-2-3). Demographic data, comorbidities, Charlson comorbidity indexes, Acute Physiology and Chronic Health Evaluation scores, laboratory results, and mortality data were examined. The data obtained were compared between the groups.

The findings may help improve clinical awareness and guide management strategies in intensive care unit patients with COVID-19 at risk of AKI

Full description

This retrospective, single-center observational study was conducted at Ankara University Hospital. Data from 238 COVID-19 patients monitored in the Anesthesiology and Reanimation Intensive Care Unit of Ankara University Ibni Sina Hospital between January 1, 2021 and January 1, 2022 were retrospectively reviewed. The objective of the study was to investigate the frequency, risk factors, and impact on mortality of acute kidney injury (AKI) in adult patients hospitalized with confirmed COVID-19 infection.

Patients with a confirmed diagnosis of COVID-19 and available renal function data were included in the analysis. AKI was defined and staged according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Demographic characteristics, comorbidities, laboratory values, and clinical parameters were evaluated to identify potential risk factors for AKI development. The relationship between the presence and severity of AKI and in-hospital mortality was assessed.

The study aims to provide insight into the burden of COVID-19-associated AKI and to support improved clinical decision-making for identifying and managing high-risk patients in hospital settings.

Enrollment: 238 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 years or older
• Hospitalized patients with COVID-19 confirmed by PCR test
• Required follow-up in the intensive care unit between January 1, 2021 and January 1, 2022

Exclusion criteria

• Patients with end-stage renal disease (ESRD)
• History of renal transplantation
• Intensive care unit stay shorter than 48 hours

Trial design

238 participants in 4 patient groups

non-AKI

stage 1 AKI

stage 2 AKI

stage 3 AKI