Acute Kidney Injury in Patients With Liver Cirrhosis

Sohag University

Status: Enrolling

Conditions: Acute Kidney Injury in Patients With Liver Cirrhosis

Treatments: Diagnostic Test: serum creatinine

Study type: Observational

Funder types: Other

Identifiers

NCT06343389

Soh-Med-24-03-14MS

Details and patient eligibility

About

In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis at Sohag University Hospital.

Full description

Acute kidney injury (AKI) is a common condition in patients with cirrhosis. It occurs in up to 50% of hospitalized patients with cirrhosis and in 58% of such patients in the intensive care unit. AKI is one of the key predictors for short-term mortality in patients with liver cirrhosis with mortality rates as high as 90%. There is a remarkable increase in length of hospital stay with high financial burden on patients with AKI.

In general, the three main causes of AKI are renal hypoperfusion (also referred to as prerenal AKI), which in most cases is due to hypovolemia; intrinsic, structural kidney injury; and postrenal injury due to urinary obstruction. A unique cause of AKI due to renal hypoperfusion in patients with cirrhosis is the hepatorenal syndrome (HRS), which is the result of renal vasoconstriction. Early identification and management of AKI may improve outcomes.

In our locality, limited studies have discussed AKI in patients with liver cirrhosis and its outcome, therefore we aim to highlight the incidence, patterns, risk factors, and outcomes of acute kidney injury in patients with liver cirrhosis.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Cirrhotic patients ( age more than 18 years old ) in Sohag University Hospital

Exclusion criteria

• patients with known preexisting chronic kidney disease
• patients who had undergone renal transplantation
• malignancy
• pregnancy

Trial design

200 participants in 2 patient groups

group A

Description:

Cirrhotic patients with Acute kidney injury

Treatment:

Diagnostic Test: serum creatinine

group B

Description:

Cirrhotic patients without Acute kidney injury

Treatment:

Diagnostic Test: serum creatinine