Acute Kidney Injury in Poly Trauma Patients

Assiut University

Status: Not yet enrolling

Conditions: Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06108765

Acute kidney injury in trauma

Details and patient eligibility

About

The aim of this study is to identify the incidence and the factors associated with acute kidney injury in adult poly trauma patients

Full description

Trauma causes significant morbidity and mortality in all age groups but particularly for those below 60 years and is one of the top 5 causes of death (1,2).Most deaths occur in adults who are between 15 and 44 years(3).Polytrauma originates from the Greek words poly which means multiple and trauma which means wounds. The term polytrauma, which was defined using the new Berlin definition, as cases with an Abbreviated Injury Scale (AIS)≥3 for two or more different body regions and one or more additional variables from five physiologic parameters (hypotension[systolic blood pressure≤90 mmHg], unconsciousness[Glasgow Coma Scale score≤8], acidosis [base excess≤ -6.0], coagulopathy [partial thromboplastin time≥40 s or international normalized ratio≥1.4], and age [≥70 years]) [4].There are complex pathophysiological changes that happen in a polyrauma patient which requires effective treatment for improving morbidity and mortality outcomes. Hemorrhage, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are some of the complications of trauma whose effects are not only local but also systemic. There are mechanisms and triggers which result in cardio-vascular shock, hemostasis, apoptosis, organ dysfunctions and immune suppression (CHAOS) [5]. These local and systemic pathophysiological changes that occur in polytrauma (CHAOS) eventually lead to Acute Kidney Injury (AKI) which further worsens their outcomes [6,7].

Enrollment: 100 estimated patients

Sex: All

Ages: 16 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The present study will be conducted on patients with multiple trauma of both genders "without intently selected certain gender" who have no previous history of kidney disease or chronic illness.

Exclusion criteria

• • Patients who are less than 16 years old.

  • Patients with preexisting kidney disease or localized individual trauma.
  • patients with diabetes and hypertension.
  • Patients Post cardiac arrest
  • patients leaving the hospital on the same day or transferred to a different hospital will be excluded from this study.
  • patients refusing study will be excluded.