Acute Liver Injury in Patients With Pneumonia

Assiut University

Status: Not yet enrolling

Conditions: Pneumonia; Acute Liver Injury

Treatments: Other: Acute Liver Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06103981

Acute Liver Injury

Details and patient eligibility

About

Acute liver injury (ALI) is defined as an acute derangement in liver function tests associated with liver-related coagulopathy, in the absence of underlying chronic liver disease.

A subset progress to acute liver failure ,Acute liver failure represent a more severe liver injury results in hepatic encephalopathy

Full description

Acute liver injury is associated with a spectrum of haemostatic changes, including thrombocytopenia and reduced platelet function, reduced plasma levels of many coagulation factors such as factor (F)VII and increased levels of FVIII .

Pneumonia is an acute inflammation of the lower respiratory tract. Lower respiratory tract infection is a major cause of mortality worldwide .Pneumonia is most common at the extremes of life.

In adults, pneumonia can be broadly classified, on the basis of chest radiographic appearance, into lobar pneumonia, bronchopneumonia and pneumonia producing an interstitial pattern.

There is lack of data regarding outcome and hospital stay in patients with pneumonia who develop acute liver injury.

Enrollment: 176 estimated patients

Sex: All

Ages: 18 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with pneumonia that developed Acute Liver Injury
2. Covid 19 pneumonia
3. Patients With acute liver injury only.

Exclusion criteria

1. Cancer
2. Immunocompromised patients i.e HIV patients and patients who take immunosuppressive medications.
3. Patients who younger than 18 yrs old
4. pregnancy

Trial design

176 participants in 2 patient groups

Group A

Description:

About 88 patients having pneumonia and developed acute liver injury That need observation of the outcome and hospital stay to evaluate acute liver injury impact

Treatment:

Other: Acute Liver Injury

Group B

Description:

About 88 patients having pneumonia but did not develop acute liver injury that need observation of the outcome and hospital stay

Treatment:

Other: Acute Liver Injury