Acute Lung Injury After Cardiac Surgery: Pathogenesis (ALI)

Aalborg University Hospital

Status: Completed

Conditions: Metabolic Disturbances; Inflammation; Postoperative; Dysfunction Following Cardiac Surgery; Acute Lung Injury; Coagulation; Intravascular

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT02475694

N-20080016

Details and patient eligibility

About

The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.

Full description

Acute lung injury after cardiac surgery is a common complication. The pathophysiology is complex and still not fully elucidate. No specific biomarkers are identified and the diagnosis is solely based on impaired oxygenation.

The purpose of the present study is to identify biomarkers of inflammation and coagulation in blood withdrawn simultaneous from the pulmonary artery and the left atrium during surgery and up to 20 hours after weaning from cardiopulmonary bypass.

Enrollment: 50 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective surgery
• CABG
• In treatment with statins

Exclusion criteria

• Acute surgery
• Valve replacement
• In treatment with immunodepressive drugs