Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord

University of Louisville (UOFL)

Status: Withdrawn

Conditions: Spinal Cord Injuries

Treatments: Device: Cervical Transcutaneous Electrical Spinal Cord Stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT04843137

20.0593

Details and patient eligibility

About

The purpose of this study is to examine how delivery of subthreshold electrical stimulation of the spinal cord alters the excitability of neural pathways and consequently movement performance in healthy and spinal cord injured individuals. Specifically, we assess how stimulation parameters such as electrode configurations and stimulation frequency affect spinal excitability, corticospinal excitability, intracortical excitability, motor unit properties and force production. This study is not an intervention study, but a mechanistic study trying to shed light on how this novel neuromodulatory technique acutely affects the central nervous system.

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• cervical level injury (C5 to C7)
• at least 1 year post-injury

Exclusion criteria

• individuals with damage to the nervous system other than to the spinal cord
• pregnant women (effects of stimulation on the fetus are unknown).

Transcranial magnetic stimulation-specific exclusion criteria:

• participants with active or inactive implants including cardiac pacemakers, implantable defibrillators, ocular implants, deep brain stimulators, vagus nerve stimulator, and implanted medication pumps
• participants with conductive, ferromagnetic or other magnetic-sensitive metals implanted in their head
• participants with a history of seizures or epilepsy
• participants taking any medication which may reduce seizure threshold

Trial design

0 participants in 1 patient group

Individuals with cervical spinal cord injury

Description:

Cohort of individuals who have experiences a chronic spinal cord injury at the cervical level (specifically C5-C7).

Treatment:

Device: Cervical Transcutaneous Electrical Spinal Cord Stimulation