Acute Medium Chain Triglycerides (MCT) Intake in Young and Older Participants (Opti-MCT)

Université de Sherbrooke

Status: Completed

Conditions: Ketonemia

Treatments: Dietary Supplement: No MCT intake with lunch, no breakfast; Dietary Supplement: 20g of Betaquik; Dietary Supplement: 10g of Betaquik; Dietary Supplement: No MCT intake with breakfast, no lunch; Dietary Supplement: 10g of Betaquik with low-carbs breakfast; Dietary Supplement: 10g of Betaquik with lunch, no breakfast

Study type: Interventional

Funder types: Other

Identifiers

NCT03830268

2017-714

Details and patient eligibility

About

Compare plasma metabolites following different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young and older participants.

Enrollment: 20 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 10 health young (20-40 y old) and 10 health older (> 60 y old) participants
• Men and women

Exclusion criteria

• smoking
• diabetes (fasting glucose >7.0 mmol/l and glycated hemoglobin >6.9%)
• strenuous aerobic exercise more than three times a week
• untreated hypertension, dyslipidemia, and abnormal renal, liver, heart or thyroid function
• under medication known to affect triglycerides and carbohydrates metabolism (i.e. diuretics, beta-blockers, steroids, insulin sensitizing)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

MCT intake in young participants

Experimental group

Description:

Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in young participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)

Treatment:

Dietary Supplement: 10g of Betaquik with lunch, no breakfast

Dietary Supplement: 10g of Betaquik with low-carbs breakfast

Dietary Supplement: No MCT intake with breakfast, no lunch

Dietary Supplement: 20g of Betaquik

Dietary Supplement: 10g of Betaquik

Dietary Supplement: No MCT intake with lunch, no breakfast

MCT intake in older participants

Experimental group

Description:

Different conditions paired with a dietary MCT beverage over an 8-hour metabolic day protocol in older participants. Interventions: 1. No MCT intake with breakfast, no lunch (i.e. CTL) 2. No MCT intake with lunch, no breakfast (i.e CTL inverted) 3. 10g of Betaquik with breakfast, no lunch (i.e BQ10) 4. 20g of Betaquik with breakfast, no lunch (i.e BQ20) 5. 10g of Betaquik with low-carbs breakfast, no lunch (i.e BQ10LC) 6. 10g of Betaquik with lunch, no breakfast (i.e BQ10 inverted)

Treatment:

Dietary Supplement: 10g of Betaquik