Acute Neuroimmune Effects of Alcohol Using Free Water Imaging

Brown University

Status

Completed

Conditions

Alcohol Drinking

Treatments

Drug: Ethanol

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT03370783

P20GM103645 (U.S. NIH Grant/Contract)

1608001583

Details and patient eligibility

About

This study examines the effects of moderate alcohol intake on the brain, the immune system, and cognition.

Full description

The study involves a within-subjects, pre/post design to assess the effects of a moderate dose of alcohol on immune biomarkers, neurobiological measures, and cognitive functioning. The study recruits healthy adults (ages 21-45) from the community to complete the experimental protocol. Participants complete magnetic resonance imaging scans, blood sample collection, and cognitive testing in the context of alcohol consumption.

Enrollment

25 patients

Sex

All

Ages

21 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Ages 21-45 years
Able to speak and read English at least at 8th grade level
Moderate self-reported alcohol use in the past year
Body mass index in normal to overweight range
Right-handed

Exclusion criteria

History of heavy drinking
Currently seeking alcohol or drug treatment
Chronic disease requiring use of medication
Recent antibiotic or probiotic use
Chronic daily use of NSAIDs
Chronic GI disorder
Use of illicit drugs
Major psychiatric disorder or suicidality
Fainting, weakness, infection, excessive bruising, or distress resulting from standard blood draw
Safety contraindication for MRI scan
Inability to abstain from use of tobacco products prior to or during study
Inability to abstain from use of cannabis prior to or during study
Pregnant, nursing, or may become pregnant