Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?

Université de Sherbrooke

Status: Completed

Conditions: Heart Failure

Treatments: Dietary Supplement: exogenous ketone salt supplement; Dietary Supplement: exogenous carbohydrate supplement

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05651529

2023-4720

Details and patient eligibility

About

Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?

Full description

This study will help to quantify heart and kidney ketone uptake with or without an exogenous ketone salt in heart failure condition.

Participants will have 2 different cardiac MRI to perform:

1. Fasting with exogenous ketone salt supplement
2. Fasting with exogenous carbohydrate supplement

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with heart failure with left ventricle ejection fraction of 40%
• Heart failure of ischemic or dilated etiology
• Ambulatory patient with a NYHA functional class of II-III;
• Stable symptoms and no change in medical therapy in the last month.

Exclusion criteria

• Diabetes
• Patients treated with any SGLT2i;
• Chronic kidney disease
• Acute coronary syndrome in the last 3 months;
• Use of parenteral inotropic agents;
• Persistent or permanent atrial fibrillation or atrial flutter;
• Presence of pacemaker or defibrillator;
• Medical condition that causes malabsorption of the test material;
• Under ketogenic diet, or using exogenous ketone supplements
• Use of nicotinamide adenine dinucleotide (NAD) precursor supplements

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

Ketone

Active Comparator group

Treatment:

Dietary Supplement: exogenous ketone salt supplement

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: exogenous carbohydrate supplement