Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft

Seoul National University

Status: Enrolling

Conditions: End Stage Renal Disease; Transplantation

Treatments: Drug: Rocuronium bromide

Study type: Interventional

Funder types: Other

Identifiers

NCT02827435

Roc_KTPL_PKPD

Details and patient eligibility

About

Reperfusion of renal graft in kidney transplantation can change the pharmacokinetic-pharmacodynamic (PKPD) parameters of rocuronium. The immediate increase of urine output during surgery may change the PKPD parameters of the drugs, including elimination rate. The goal of this study is to characterize the PKPD model of rocuronium during kidney transplantation and establish a basis for adequate dosage of rocuronium in kidney transplantation.

Through PKPD modeling, the changes during reperfusion of the renal graft will be evaluated. Furthermore, the factors related to the changes will be assessed. Adjusting the infusion rate according to the step of kidney transplantation will lead to stable muscle relaxation and fast recovery.

Enrollment: 12 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled for elective living donor kidney transplantation
• end stage renal disease with oliguria or anuria
• normal BMI (BMI 18.5 ~ 25)
• obtained informed consent

Exclusion criteria

• patient with underlying neuromuscular disease

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Rocuronium bolus

Experimental group

Description:

rocuronium bromide 1st bolus 0.1mg/kg, rocuronium bromide 2nd bolus 0.4mg/kg

Treatment:

Drug: Rocuronium bromide