Acute Phase Reactions and Thrombophilia in Pediatric Patients With Migraine

HaEmek Medical Center, Israel

Status: Unknown

Conditions: Thrombophilia; Migraine

Treatments: Other: Laboratory tests

Study type: Interventional

Funder types: Other

Identifiers

NCT01905748

0040-09-EMC

Details and patient eligibility

About

Acute Migraine attacks can be related to vascular or coagulation activation. Previous studies found relative high incidence of prothrombotic events in Migraine. The present study intends to assess the coagulation system and activation in patients with Migraine during steady state phase and at the beginning of attacks and after 72 hours. A control group of patients with another acute neurologic event like convulsions will be also studied. Patients will be at pediatric age and teenagers.

Enrollment: 15 estimated patients

Sex: All

Ages: 5 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients at the pediatric age (5 to 20 ys old) suffering from Migraine attacks diagnosed by a neurologist.

Exclusion criteria

• Patients with other underlying neurological conditions of coagulation diseases

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Patients during Migraine attacks

Experimental group

Description:

Patients with Migraine before, during and after Migraine attacks. Acute phase reaction profile, and activation of the coagulation system will be investigated together with thrombophilia profile.

Treatment:

Other: Laboratory tests

Control group

Experimental group

Description:

Patients with acute neurologic events like convulsions not related to fever or central nervous system (CNS) infections will be studied including acute phase reaction laboratory tests, thrombophilia and activation of the coagulation system

Treatment:

Other: Laboratory tests