Acute Single Meal Effects of Trout on Cardiovascular Risk Markers and Plasma Proteome

University of Copenhagen

Status: Unknown

Conditions: Cardiovascular Diseases; Metabolic Syndrome

Treatments: Behavioral: Intake of rainbow trout from different feeding conditions versus a control poultry meal

Study type: Interventional

Funder types: Other

Identifiers

NCT00432952

M186

Details and patient eligibility

About

The acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated.

The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.

Full description

In a controlled, single blinded human single meal study the acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated. 6 healthy men, age 40-70, will be randomized to trout fed on only vegetable, only marine and a mix of different compositions of vegetable and marine feeds. Outcome variables are blood pressure, pulse wave analyse, pulse wave velocity, plasma protein profile, and plasma triglycerides.

The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.

Sex: Male

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non regular smokers
• Body Mass Index (18.5-30 kg/m2)
• Able to eat fish

Exclusion criteria

• Exercise >10 h/week
• Chronical diseases (eg. cardiovascular and diabetes)
• Regular medication
• Fish oil supplementation
• Blood donation 2 month prior or during participation
• Above maximum recommended alcohol intake
• Blood pressure >160/100 mm Hg

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind