Acute Vascular Response to Exercise in Women With Nonobstructive Coronary Artery Disease
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About
The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease.
Full description
Women are more likely to have nonobstructive coronary artery disease (CAD) . The purpose of this study is to examine the acute effect of exercise on vascular function in women with nonobstructive coronary artery disease. Endothelium-dependent and -independent dilation, arterial stiffness and wave reflection will be measured at baseline and after walking on a treadmill at a slow pace for 47 minutes. Endothelium-dependent dilation will be measured using brachial artery flow-mediated dilation via high resolution ultrasonography. Endothelium-independent dilation will be measured using brachial artery dilation to sublingual nitroglycerin. Arterial stiffness and wave reflection will measured using applanation tonometry.
Enrollment
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Volunteers
Inclusion criteria
- women with non-obstructive coronary artery disease documented within the past 5 years by coronary angiogram as no coronary arteries with stenosis greater than 50% lesions
- age 18 to 89 years
- able to complete maximal graded exercise test
Exclusion criteria
- use of tobacco products within the previous six months
- use of oral contraceptives or hormone replacement therapy within the prior year
- pregnancy (positive urine pregnancy test) or lactation
- history of hepatic disease or infection with hepatitis B, C or HIV
Trial design
Primary purpose
Allocation
Interventional model
Masking
7 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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