Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers

Karolinska University Hospital

Status and phase: Completed; Phase 4

Conditions: Anesthetics; Hypercapnia; Conscious Sedation; Hypoxia

Treatments: Procedure: Hypercapnic ventilatory response; Procedure: Hypoxic ventilatory response

Study type: Interventional

Funder types: Other

Identifiers

NCT01873612

PropDexHVRVolunteers

Details and patient eligibility

About

The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.

Full description

15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study.

6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.

Enrollment: 11 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Male
2. Age 18-40
3. American Society of Anesthesiologist´s classification (ASA) 1, i.e. healthy
4. No medication
5. No allergies
6. Non-smoker/no snuff, i.e. no nicotine intake
7. Normal weight, BMI <26

Exclusion criteria

Snoring

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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11 participants in 2 patient groups

Sedation with dexmedetomidine

Experimental group

Description:

Sedation with dexmedetomidine

Treatment:

Procedure: Hypoxic ventilatory response

Procedure: Hypercapnic ventilatory response

Sedation with propofol

Experimental group

Description:

Sedation with propofol

Treatment:

Procedure: Hypoxic ventilatory response

Procedure: Hypercapnic ventilatory response