Acylcarnitine Profile After Intensive Care

University of Liege

Status: Enrolling

Conditions: Critical Care; Carnitine Metabolism Disturbances

Treatments: Diagnostic Test: Serum acylcarnitine profiling

Study type: Observational

Funder types: Other

Identifiers

NCT05115734

CARNUSI

Details and patient eligibility

About

The aim of the study is to compare the acylcarnitine profile of critically ill survivors of a prolonged stay in ICU with the profile of survivors of short ICU length of stay. The second aim is to assess the evolution of the acylcarnitine profile over time in survivors of a prolonged ICU stay.

Full description

In a retrospective analysis focused on survivors of an ICU stay of 7 days or more, we showed that during the week following discharge, carnitine deficiency was rare, but acylcarnitine profile was altered, with an abnormal acylcarnitine/carnitine ratio in more than 25% of the population.

Carnitine has a key role in cellular energy metabolism and is a a biomarker of the mitochondria function. Moreover, mitochondrial function is proven to be severely impaired in critically ill patients and mitochondrial dysfunction has been linked to post-ICU disorders.

In this context, it is relevant to study the evolution over time of the acylcarnitine profile in ICU survivors of a prolonged ICU stay. It is also relevant to compare the same profile between survivors of a prolonged and a shorter ICU stay.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Group short stayers: ICU length of stay of 2 days
• Group long stayers: ICU length of stay of at least 7 days

Exclusion criteria: patient refusal

Trial design

100 participants in 2 patient groups

Short stayers

Description:

Determination of the acylcarnitine profile during the 5 days following discharge of a short stay in ICU (maximum 2 days)

Treatment:

Diagnostic Test: Serum acylcarnitine profiling

Long stayers

Description:

Determination of the acylcarnitine profile during the year following discharge of a prolonged stay in ICU (7 days or more)

Treatment:

Diagnostic Test: Serum acylcarnitine profiling