ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)

University of Washington

Status

Enrolling

Conditions

Obesity

Treatments

Behavioral: Behavioral Weight Loss Program

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT06174389

R01DK134417 (U.S. NIH Grant/Contract)

STUDY00017667

Details and patient eligibility

About

Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.

Full description

Participants will be asked to enroll for 18-months. Each participant will complete 3 in-person study visits, then participate an a 6-month weight loss program delivered remotely. Some participants may be invited to complete 3 additional in-person visits. Study Visit activities include questionnaires, blood draws, brain MRIs, body measurement and dual energy x-ray absorptiometry (DXA) scan for body composition measurement, a breathing test, and biopsies of muscle and fat tissue. Each participant will be provided a fitness tracker and body weight scale to use throughout the study.

Enrollment

90 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

BMI 30.0 - 50.0 kg/m2
Able to attend study intervention classes and study visits/assessments
Independently living with access to food preparation facilities

Exclusion criteria

Current smoker or regular use of nicotine containing products and/or cannabis
Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
Known cognitive impairments or h/o stroke
Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
History of bariatric surgery
History of eating disorder
Current participation in a formal weight loss program
Prior or current participation in a research study involving weight loss
Weight-reduced by >10% within past year
Weight > 330 pounds (MRI limit)
Allergy or intolerance to or unwillingness to consume study foods provided at visit
MRI contraindication (e.g., implanted metal, claustrophobia)
Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate