Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness (Surnutrition)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Constitutional Thinness; Lipid Overnutrition

Treatments: Behavioral: Lipid overnutrition

Study type: Observational

Funder types: Other

Identifiers

NCT01224561

DGS2007-0536 (Other Identifier)

2007-A00744-49 (Other Identifier)

0701047

Details and patient eligibility

About

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Full description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Enrollment: 26 estimated patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• consent form the study signed
• consent form for genetic study signed
• normal laboratory values for liver enzymes, glucose, lipid

Exclusion Criteria (common to the two groups):

• pregnant
• vegetarian
• heavy smoking
• heavy alcohol
• depressive
• taking hypolipidemic or antihypertensive drugs
• dyslipidemia

Trial design

26 participants in 2 patient groups

Constitutional thinness

Description:

Women with a a body mass index of less than 16.5 kg/m2

Treatment:

Behavioral: Lipid overnutrition

Healthy Volonteer

Description:

Women with a body mass index between 20 and 25 kg/m2

Treatment:

Behavioral: Lipid overnutrition