Adaptations to Breast Cancer and Exercise (ABRACE)

João Henkin

Status: Enrolling

Conditions: Breast Cancer

Treatments: Other: Combined training; Other: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT03314168

72983017.3.0000.5347

Details and patient eligibility

About

This study aims to investigate the effects of different volumes of combined training on fatigue, neuromuscular variables, morphological, cardiorespiratory capacity, functionality, and quality of life, in breast cancer (BCa) women undergoing primary treatment. Two thirds will be the intervention group that will perform combined training, while the other third will be the control group that will have physiotherapy sessions.

Full description

Although chemotherapy and radiation are mainstream treatment modalities, patients will often experience treatment-related side effects such as impairments to the neuromuscular and cardiovascular systems and reduction in quality of life (QoL).To date, numerous positive effects on neuromuscular and aerobic parameters in response to resistance and aerobic training have been reported when both training modalities were simultaneously performed (i.e. combined training - COMB) in BCa patients. However, there is a lack of data regarding the prescription of this modality in BCa patients, as the necessary dose of resistance training for significant improve in fatigue, neuromuscular, and quality of life. In this sense, no previous studies investigate the effect of different volumes of resistance training in BCa patients, providing important informations about the prescription in this clinical population.

Enrollment: 84 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Breast cancer diagnostic at I and II stages;
• Adjuvant or neoadjuvant chemotherapy (≤50% of sessions completed);
• More than 18 years.

Exclusion criteria

• Current smoking
• Diabetic neuropathy;
• Hypertension uncontrolled;
• Heart failure;
• Clinical depression;
• Skeletal muscle impairment which not allow physical exercise.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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84 participants in 3 patient groups

Control group

Active Comparator group

Description:

Patients who are randomized in control group will receive the usual care in their respective hospital.

Treatment:

Other: Control group

Single-set group

Experimental group

Description:

Patients who are randomized in Single-set (SS) group, will receive 12-week of combined training, twice a week, composed by 10 resistance exercises and 20-25 minutes aerobic exercise at 80-95% of the second ventilatory threshold heart rate in a cycle. One-single set will be performed per exercise at 60-80%1-RM, with 1-1,5min of rest between the exercises.

Treatment:

Other: Combined training

Multiple-sets group

Experimental group

Description:

Patients who are randomized in Multiples-set (MS) group, will receive 12-week of combined training, twice a week, composed by 10 resistance exercises and 20-25 minutes aerobic exercise at 80-95% of the second ventilatory threshold heart rate in a cycle. Regarding resistance exercises, three set will be performed per exercise at 60-80%1-RM, with 1-1,5min of rest between sets and the exercises.

Treatment:

Other: Combined training