Adapting Project UPLIFT for Hispanic Patients With Epilepsy II

NYU Langone Health

Status: Completed

Conditions: Epilepsy

Treatments: Behavioral: Usual Care; Behavioral: Using Practice and Learning to Increase Favorable Thoughts

Study type: Interventional

Funder types: Other

Identifiers

NCT03000725

16-01531

Details and patient eligibility

About

The purpose of this study is to adapt Project UPLIFT for Hispanic adults with epilepsy and depression. Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a home-based intervention that teaches cognitive and mindfulness skills to people with epilepsy by phone to reduce their depression and improve quality of life (QOL); it was developed at Emory University with CDC funding. The purpose of this study is to adapt Project UPLIFT for Hispanic adults with epilepsy and depression. Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a home-based intervention that teaches cognitive and mindfulness skills to people with epilepsy by phone to reduce their depression and improve quality of life (QOL); it was developed at Emory University with CDC funding.

Full description

The goal of this study is to adapt Project UPLIFT for Hispanic adults with epilepsy and depression. A 2-arm randomized control trial will be conducted to evaluate the feasibility, acceptability and effects of Project UPLIFT versus usual care (UC) in Hispanic patients with epilepsy.

The specific aim of this study is: To evaluate the feasibility, acceptability and short- and long-term effects of the adapted intervention on depression and other outcomes in 72 English- and Spanish-speaking Hispanic epilepsy patients.

Enrollment: 72 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• self-identified as Hispanic
• English or Spanish speaking
• diagnosis of epilepsy for at least one year post diagnosis
• willing to participate in 8 one-hour telephone sessions every week for eight weeks.
• willing to be audio-taped
• Elevated depressive symptoms (Center for Epidemiological Studies Depression Scale (CES-D) score >13

Exclusion criteria

• Severe depression (CES-D > 37)
• Active suicidal ideation
• Significant cognitive impairment (evident during screening)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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72 participants in 2 patient groups

UPLIFT

Active Comparator group

Description:

Project UPLIFT (Using Practice and Learning to Increase Favorable Thoughts) is a home-based intervention that teaches cognitive and mindfulness skills to people with epilepsy by phone to reduce their depression and improve quality of life (QOL).

Treatment:

Behavioral: Using Practice and Learning to Increase Favorable Thoughts

USUAL CARE

Active Comparator group

Description:

Participants randomized to the UC group will receive printed educational materials on management of epilepsy in English or Spanish as preferred.

Treatment:

Behavioral: Usual Care