Adaptive and Trained Immunity in the Pathogenesis of IgG4-Related Disease (TRIM4)

San Donato Group (GSD)

Status: Active, not recruiting

Conditions: IgG4 Related Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06844864

2022FH5R92 (Other Grant/Funding Number)

Details and patient eligibility

About

Enquire involvement of trained immunity in the pathogenesis of IgG4RD

Full description

Enquire involvement of trained immunity in the pathogenesis of IgG4RD using primary macrophages and co-cultures with patient derived fibroblasts. The investigators will first assess whether macrophages from patients are trained compared to macrophages of healthy controls and then challenge them with IgG from IgG4RD patients to evaluate the functional effects on cultivated fibroblasts.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients:

• Adult subjects > or = 18 years of age
• Subjects capable of providing informed consent
• Active IgG4-RD based on the IgG4-related disease activity index
• Fulfillment of the 2019 ACR/EULAR Classification Criteria for IgG4RD

Healthy Controls:

• Adult subjects > or = 18 years of age
• Subjects capable of providing informed consent

Exclusion criteria

Patients and healthy controls:

• Subjects < 18 years of age
• Pregnant women
• Comorbidities (other ongoing active autoimmune diseases, ongoing cancer, ongoing infections)
• Ongoing immunosuppressive therapy