ClinicalTrials.Veeva

Menu

Adaptive Cognitive Training on Cognitive Function in Elderly Hypertension Patients in the Community

P

Peking University

Status

Not yet enrolling

Conditions

Aging
Hypertension
Condition

Treatments

Device: adaptive cognitive training
Device: placebo cognitive training

Study type

Interventional

Funder types

Other

Identifiers

NCT06512922
CMB22-466

Details and patient eligibility

About

Objective A growing body of evidence supports hypertension as a risk factor for cognitive decline. Hypertension is significantly associated with accelerated cognitive decline, poorer cognitive function, and mild cognitive impairment and dementia. Cognitive training is an effective intervention to improve cognitive function. However, the current cognitive training does not fully consider the different areas and degrees of cognitive function impairmentof older adults. This study aims to evaluate the effect of adaptive cognitive training on cognitive function of older adults with hypertension in the community.

Participants Age 60 years or older, diagnosis of hypertension, and cognitive function assessment showed no dementia.

Design The study was designed as a double-blind randomized controlled trial. 120 hypertension participants without dementia aged 60 years or older in Shijingshan, Beijing were included. Participants will be randomized to adaptive cognitive training (intervention group) and placebo cognitive training (control group) at a ratio of 1:1. Both training will be delivered by using PADs with the same appearance. The interventions will last for 6 months and follow up to 12 months, and both groups will be followed up on the same time schedules for all outcome measurements. The primary outcome is changes in MoCA scores from baseline to the end of the 6-month intervention.

The current trial has been reviewed by the Ethics Committee of Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (approval number: 2024-162).

Enrollment

120 estimated patients

Sex

All

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ① with a clear diagnosis of hypertension (according to ICD-10 or DSM-Ⅳ criteria), systolic blood pressure range 130-160 MMHG, maintaining the original hypertension treatment strategy; ② age ≥60 years old; ③ literate and able to use smart phone or tablet computer skillfully, with CAIDE dementia risk score >9, but without a diagnosis of dementia (ICD-10 or DSM-Ⅳ dementia diagnostic criteria); ④ have lived in the target community for at least 6 months and continue to live in the original community for the next 12 months.

Exclusion criteria

  • A cardiovascular event (hospitalization for stroke) or surgery in the previous 12 months; Alcohol or drug abuse in the past 12 months; Families, important people of participants in the study have concerns; Live in the same household as a participant who has been randomly assigned; Severe aphasia, physical disability, or any other factor that may prevent completion of neuropsychological testing; Use of medications that may affect cognition, including sedatives, anxiolytics, hypnotics, nootropics, and cholinergic drugs; Refusing or not receiving cognitive training; currently participating in another clinical trial.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

120 participants in 2 patient groups

adaptive cognitive training
Experimental group
Description:
The intervention lasted for 6 months. Participants will receive 30 minutes of training per day, at least five days per week. In each task, once a high accuracy (e.g. \>80%) is achieved, the task is automatically upgraded to the next difficulty level.
Treatment:
Device: adaptive cognitive training
placebo cognitive training
Active Comparator group
Description:
The intervention lasted for 6 months. Participants will receive 30 minutes of training per day, at least five days per week. The tasks will be set to a fixed level of difficulty.
Treatment:
Device: placebo cognitive training

Trial contacts and locations

0

Loading...

Central trial contact

Wuxiang Xie, PhD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems