Adaptive DBS to Offset STN Dysregulation During Exercise in PD

University of Colorado Denver (CU Denver)

Status: Enrolling

Conditions: Parkinson Disease

Treatments: Device: aDBS

Study type: Observational

Funder types: Other

Identifiers

NCT06296810

23-0847

Details and patient eligibility

About

The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.

Full description

The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.

Enrollment: 10 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.

Exclusion criteria

Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.

Trial design

10 participants in 1 patient group

PD

Description:

Subjects with PD who have an implanted Medtronic DBS system with a Percept IPG.

Treatment:

Device: aDBS