Adaptive Immune Response to Seasonal Influenza Vaccination (AIGI)

University Medicine Greifswald

Status: Active, not recruiting

Conditions: Seasonal Influenza Vaccination

Treatments: Drug: Vaxigrip Tetra 2020/2021

Study type: Observational

Funder types: Other

Identifiers

NCT05129436

AIGI

Details and patient eligibility

About

AIGI (Adaptive Immune Response to Seasonal Influenza Vaccination) is a prospective clinical study aiming at studying the kinetics of vaccine-specific antibody production after seasonal influenza vaccination in health care workers.

Full description

AIGI (Adaptive Immune Response to Seasonal Influenza Vaccination) is a prospective clinical study aiming at elucidating the kinetics of vaccine-specific antibody production after seasonal Influenza vaccination in health care workers at the Greifswald University hospital. Participants were recruited before their intended vaccination.

Participants received the influenza vaccine Vaxigrip Tetra 2020/2021 by Sanofi Pasteur Europe.

Within the study, volunteers donate peripheral blood by venipuncture on the day of vaccination as well as 7 and 14 days after vaccination. EDTA plasma and peripheral mononuclear cells (PBMCs) are prepared and stored at -20 °C.

Volunteers are also asked to complete a standardized questionnaire on each day of blood sampling. Questionnaires collect data about physical characteristics, seasonal influenza vaccinations, current infections, medication, immune relevant diseases and side effects of the vaccination.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned participation in seasonal influenza vaccination
• Completion of the 18th year of life
• verbal and written consent given

Exclusion criteria

• current infectious diseases
• underweight (BMI<18,5)
• blood coagulation disorders, anemia or similar diseases
• known congenital or acquired immunodeficiencies

Trial design

20 participants in 2 patient groups

Establishment of method

Description:

healthy volunteers who are asked to donate peripheral blood for the establishment of the method

Influenza vaccination

Description:

Subjects receiving the influenza vaccine Vaxigrip Tetra 2020/2021 by Sanofi Pasteur Europe.

Treatment:

Drug: Vaxigrip Tetra 2020/2021