Adaptive Pet Study

Duke University

Status: Completed

Conditions: Lung and Esophagus Cancers; Anal, Cervix, Vulvar, Vaginal, and Endometrium Cancers; Head and Neck Cancers

Treatments: Other: PET-CT

Study type: Interventional

Funder types: Other

Identifiers

NCT01908504

Pro00033339

Details and patient eligibility

About

The purpose of this study is to determine the benefit of using positron emission tomography (PET) in addition to the standard (computed tomography) CT to plan radiation therapy for cancer treatment. The information from the PET-CT may allow the investigators to change the radiation plan or the delivery of the radiation to the tumor/tumor site such as the total dose of radiation or the size of the area to receive further radiation. Presently the use of PET scans to adjust radiation therapy during radiation treatment is not standard of care and is being investigated in this study.

Enrollment: 271 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically (histologically or cytologically) proven diagnosis of carcinoma
• Patients with local or regional nodal disease are eligible.
• Zubrod Performance Status 0, 1, or 2.
• Age ≥ 18
• Negative serum pregnancy test for women of child bearing potential
• Patient must sign study-specific informed consent prior to study entry.

Exclusion criteria

• No gross disease visible on imaging at the start of radiotherapy
• Contraindication to PET
• Complete response by PET achieved with pre-radiation therapy treatment (surgery or chemotherapy)
• Breast feeding

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

271 participants in 1 patient group

PET-CT

Other group

Treatment:

Other: PET-CT