Adaptive Support Ventilation in the Weaning of COPD

Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Status and phase: Completed; Phase 4

Conditions: Pulmonary Disease, Chronic Obstructive

Treatments: Procedure: Comparison of two different modes for weaning from mechanical ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00969605

IGCEH-ICU-1

Details and patient eligibility

About

Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation. Weaning with ASV shows promising results mainly in post-cardiac surgery patients. The aim of this randomized controlled study was to test the hypothesis that weaning with ASV could reduce the weaning duration in patients with chronic obstructive pulmonary disease (COPD) when compared with PSV.

Enrollment: 97 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of COPD
• On invasive mechanical ventilation for at least 24 hours because of hypoxemic and/or hypercapnic respiratory failure

Exclusion criteria

• Mechanical ventilation less then 24 hours (self extubation or death),
• Having a tracheotomy and
• COPD coexisted with severe cardiac or neurologic diseases.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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97 participants in 2 patient groups

Pressure support ventilation

Active Comparator group

Treatment:

Procedure: Comparison of two different modes for weaning from mechanical ventilation

Adaptive support ventilation

Active Comparator group

Treatment:

Procedure: Comparison of two different modes for weaning from mechanical ventilation