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Rationale: It is well established that Substance Use Disorders (SUD) have severe health consequences. Despite behavioral and pharmacological treatment options, relapse rates remain high. In particular, for non-opioid drugs, such as amphetamines, cocaine, base-coke and cannabis, established, evidence-based pharmacological options to reduce craving, to substitute substance use or to enforce abstinence are lacking. Therefore, there is a need for effective interventions for patients who use non-opioid drugs to reach and maintain long-term abstinence.
A potential interesting intervention is addiction-focused Eye Movement Desensitization and Reprocessing (AF-EMDR) therapy. However, the limited research on AF-EMDR therapy and mixed findings thus far prohibit clinical use. Recently, on the basis of diverse findings thus far, an adjusted AF-EMDR therapy protocol has been developed.
Full description
Objective: to investigate areas of uncertainty about a possible future pilot RCT using AF-EMDR as an add-on intervention in inpatients who use non-opioid drugs and receive regular, inpatient addiction treatment, by determining:
Study population: adults with a primary non-opioid use disorder, who are admitted to an inpatient addiction care clinic. A total of nine eligible participants will be allocated (allocation ratio 1:1:1) at random, in a non-concurrent fashion to one of three baseline durations.
Intervention: a total of four 90 min. sessions of AF-EMDR twice per week added to TAU.
Main study parameters/endpoints:
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Inclusion criteria
In order to be eligible to participate in this study, patients must meet the following criteria:
Diagnosis of Tobacco Use Disorder according to the DSM-5 (American Psychiatric Association, 2013) criteria.
Age ≥ 18 years.
Good Dutch language proficiency (based on clinical judgement).
Smoking, on average, ≥ 10 cigarettes per day pre-admission.
A score of at least 5 on a scale from 0 to 10, for motivation and self-efficacy
A planned inpatient stay of ≥ 4 weeks.
Written informed consent.
Exclusion criteria
A patient who meets any of the following criteria will be excluded from participation in this study:
Serious therapy interfering behavior or symptoms that also interfere with TAU, based on clinical judgement (e. g. psychiatric or medical crisis that requires immediate intervention).
Primary purpose
Allocation
Interventional model
Masking
9 participants in 1 patient group
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Central trial contact
Reinier van den Haak; Wiebren Markus
Data sourced from clinicaltrials.gov
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