Addiction in Adolescence - Pathomechanisms and Treatment Evaluation (MATRIX-A)

Technische Universität Dresden

Status: Unknown

Conditions: Substance Use Disorders; Adolescent Behavior

Treatments: Other: adapted treatment according to the MATRIX-A therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03444974

MATRIX-A

Details and patient eligibility

About

This study aims to investigate the sociodemographic background as well as psychiatric comorbidities of adolescent substance users with substance use disorders. The study simultaneously evaluates biomarkers of stress and addiction, including long-term cortisol levels from hair samples and gene methylation in blood samples associated with substance use.

Our study also adapts, rolls out, and evaluates an evaluated multimodal treatment manual wich was originally intended for stimulant drug users (MATRIX). We adopt this manual to the needs and specifics of adolescents (MATRIX-A, A=adolescents) with substance use disorders of any substance, including cannabis, methamphetamine, and alcohol. Adolescents will receive group therapy sessions, individual therapy sessions, and medication if needed, while parents or professional caretaker will receive group sessions. Therapy outcomes will be examined in addition to parental distress and parenting skills.

Full description

As numbers of adolescent drug abuse have grown rapidly within the last couple of years, research on youth drug abuse and dependency has taken a new and vital role within the public healthcare system. For this reason, it is crucial to find new ways to effectively integrate adolescent patients into the health care system, as well as assign them to treatment options tailor made for the specific challenges and needs of this population. This study aims to investigate (a) sociodemographic background and psychiatric comorbidities in connection with adolescent substance abuse and dependence to enhance understanding of epidemiologic risk factors for developing drug dependency in adolescence, as well as benefit future treatment options.

It further aims to investigate (b) molecular and epigenetic mechanisms of addiction disorders in adolescents by analyzing methylation pattern, as well as proteome analysis of peripheral immune markers. The investigator's aim is a better understanding of the multimodal biological underpinnings of risk/resilience for addiction in youth on the molecular, cellular and circuit levels with a special focus on the changes within the stress and immune system in patients with addiction disorders and their family members.

Another research interest of this study concerns (c) adapting and evaluating new treatment options, tailor made for the adolescent population. For this reason the investigators aim to adapt, implement and evaluate a therapeutic program according to the MATRIX manual for the treatment of substance abuse, which consists of two group therapies for patients, as well as their parents (Evaluation time points: T0, T1, and T2).

Last, this study aims to (d) evaluate parental stress levels, parental communication skills and knowledge in connection with adolescent substance abuse.

Enrollment: 450 estimated patients

Sex: All

Ages: 12 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Adolescents:

Inclusion Criteria:

• Age 12.00-17.99
• Therapy / wait list group: current substance use disorder
• Controls: no history of substance use disorders

Exclusion Criteria:

• Preexisting neurological diseases

• Diseases of or with involvement of the central nervous system

• Intelligence quotient (IQ) < 70

• Diseases concerning the adrenal gland, pituitary gland or hypothalamus

• Acute viral diseases during T0, T1, T2

• Controls:

  • Drug intake modulating the central nervous system
  • Main psychiatric disorders
  • Current substance use

Parents:

Inclusion Criteria:

• At least one child/protégé with problematic substance abuse
• No current substance abuse on their own
• At least one parent must be eligible to participate in the group

Exclusion Criteria:

• Current substance abuse

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

450 participants in 5 patient groups

Patient therapy group

Active Comparator group

Description:

* Adolescents with substance use disorders * Receiving an adapted treatment according to the MATRIX-A therapy

Treatment:

Other: adapted treatment according to the MATRIX-A therapy

Parental therapy group

Active Comparator group

Description:

* Parents of adolescents with substance use disorders * Receiving an adapted treatment according to the MATRIX-A therapy

Treatment:

Other: adapted treatment according to the MATRIX-A therapy

Patient waiting list group

No Intervention group

Description:

* Adolescents with substance use disorders * On the waiting list for receiving a MATRIX-A therapy

Parental waiting list group

No Intervention group

Description:

* Parents of adolescents with substance use disorders * On the waiting list for receiving a MATRIX-A therapy

control group

No Intervention group

Description:

* Adolescents with no history of substance use disorders * no other intake of psychotropic substances such as psychotropic medication