Adding Desmopressin to Tamsulosin for Treatment of BPH

Mansoura University

Status and phase: Enrolling; Phase 4

Conditions: Nocturnal Polyurea in Patients With BPH

Treatments: Drug: Desmopressin Acetate; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT05945420

MS.22.12.2245

Details and patient eligibility

About

In this study investigators will add desmopressin for treatment of patients with benign prostatic hyperplasia and nocturnal polyurea

Full description

Investigators will give a group of patients tamsulosin and desmopressin and the other group will take tamsulosin and placepo and compare the outcome regarding symptoms of being prostatic hyperplasia especially nocturia and the effect on nocturnal polyurea in patients

Enrollment: 160 estimated patients

Sex: Male

Ages: 50 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Men with BPH Age more than 50years Patients with nocturia (2voids per night or More) Patients with nocturnal polyurea (urine volume More than 33%of urine allover the day) IPSS more than 12 Obstructed flow curve Post voiding residual less than 150

Exclusion criteria

• men with BPH with : Acute urine retention Neurogenic bladder dysfunction Cardiovascular disease Hyponatremia Urethral stricture Bladder calculi Prostate cancer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

160 participants in 2 patient groups, including a placebo group

Desmopressin arm

Active Comparator group

Description:

This arm will receive tamsulosin and desmopressin

Treatment:

Drug: Desmopressin Acetate

Placebo arm

Placebo Comparator group

Description:

This arm will receive tamsulosin and placepo

Treatment:

Drug: Placebo