Adding Ketamine to Levobupivacaine in Paravertebral Block in Thoracotomy

Tanta University

Status and phase

Completed

Phase 4

Conditions

Levobupivacaine

Chronic Pain

Ketamine

Acute Pain

Paravertebral Block

Treatments

Drug: Ketamine + Levobupivacaine

Drug: Levobupivacaine

Study type

Interventional

Funder types

Other

Identifiers

NCT06011746

36264PR244/6/23

Details and patient eligibility

About

To evaluate the role of adding ketamine to levobupivacaine in PVB on acute and chronic pain in thoracotomy

Full description

Several adjuvants have been added to them to enhance the effects of those blocks. Dexamethasone, morphine, dexmedetomidine, clonidine, ketamine, and magnesium sulphate are some of them. results are variable.

Ketamine blocks N-Methyl-D-Aspartate (NMDA) receptors in the spinal cord. It is also considered to influence voltage sensitive Calcium ions channels, opioid receptors, and monoaminergic receptors. Therefore, it is considered overall to affect nociception.

Enrollment

60 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18-75 years.
Both sexes.
ASA (American Society of Anesthesiology) physical status II-III.
Scheduled for open thoracotomy.

Exclusion criteria

Contraindications to or failed paravertebral block .
Body mass index (BMI) >35 kg/m2.
The likelihood of postoperative mechanical ventilation.
Patients with coagulopathy, poorly controlled diabetes mellitus, depression or other psychiatric disorders that required antidepressant drugs, alcohol, or recreational drug addiction.
Hypersensitivity to ketamine or levobupivacaine.