Addition of Lidocaine to Levobupivacaine Reduces Intrathecal Block Duration

Diskapi Teaching and Research Hospital

Status and phase: Completed; Phase 4

Conditions: Benign Prostate Hyperplasia

Treatments: Drug: levobupivacaine Spinal anesthesia; Drug: Levobupivacaine lidocaine spinal anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT01675895

DİLEKLEVOBUPİVACAİNE

Details and patient eligibility

About

The main objective was to test the hypothesis that adding lidocaine to hyperbaric levobupivacaine could change the duration of levobupivacaine spinal block.

Full description

A satisfactory spinal anaesthesia requires both a fast onset and proper duration at the same time. Transurethral resection of the prostate (TUR-P) is a surgery of medium duration. The addition of lidocaine to hyperbaric bupivacaine shortens the duration of bupivacaine spinal block and therefore provides more rapid recovery. This property of lidocaine is not verified with other local anesthetics. Levobupivacaine is a S-enantiomer of racemic bupivacaine and is a long acting local anesthetic.The aim of this prospective randomized controlled study was to investigate this effect of lidocaine, with a local anesthetic other than bupivacaine. It was hypothesized that the duration of the intrathecal block could change when performed with hyperbaric levobupivacaine mixed with low dose lidocaine and this technique could be consistent for the duration of TUR-P surgery. Participants will be followed on the day of surgery for primary and secondary outcome measures and 3 days postoperatively for complications (TNS).

Enrollment: 40 patients

Sex: Male

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective transurethral resection of the prostate (TUR-P)

Exclusion criteria

• patients with contraindications for spinal anesthesia,
• known sensitivity to the study drugs,
• emergency cases, and
• patients who refused spinal anaesthesia were excluded

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Group Levobupivacaine lidocaine

Experimental group

Description:

Group Levobupivacaine lidocaine Spinal anesthesia with 1.5 ml hyperbaric levobupivacaine (6.75 mg) + 0.3 ml 2 % lidocaine

Treatment:

Drug: Levobupivacaine lidocaine spinal anesthesia

Group Control

Active Comparator group

Description:

Group Control levobupivacaine spinal anesthesia with levobupivacaine (6.75 mg) + saline

Treatment:

Drug: levobupivacaine Spinal anesthesia