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Addition of Neostigmine to Levobupivacaine

Cairo University (CU) logo

Cairo University (CU)

Status

Completed

Conditions

Spermatic Cord Block

Treatments

Drug: Control Test
Drug: Neostigmine

Study type

Interventional

Funder types

Other

Identifiers

NCT04492319
N-18-2020

Details and patient eligibility

About

Using the spermatic cord block has been of great advantage, as it has been cost saving, efficient technique whether used inon its own or combination with a sedative or . Furthermore, it provides minimal cardiac risks, early case ambulation, satisfactory postoperative pain control, as well as a reduced hospital stay and cost. one of the major drawbacks of spermatic cord block is being a single injection technique, leading to a short postoperative analgesia duration. So, to overcome this flaw some adjuvants were proven to prolong the analgesia duration as neostigmine.

Enrollment

112 patients

Sex

Male

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients aged from 20 to 45 years.
  • American Society of Anesthesiologists I-II.
  • Undergoing Testicular Sperm Extraction Surgery.
  • BMI from 18.5 to 40 kg/m2

Exclusion criteria

  • Patient refusal
  • Contraindications to regional anesthesia (bleeding disorders e.g. international normalized ratio >1.5, Prothrombin Concentration <70%, platelet count<100 × 109, use of any anti-coagulants, local infection, etc.).
  • Known allergy to local anesthetics.
  • ASA III-IV.
  • Patients aged less than 18 or more than 60.
  • Body mass index >35.:

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

112 participants in 2 patient groups

control group
Active Comparator group
Treatment:
Drug: Control Test
neostigmine group
Active Comparator group
Treatment:
Drug: Neostigmine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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