Addition of Prednisolone and Heparin in Patients Undergoing IVF With Failed IVF Cycles

National and Kapodistrian University of Athens

Status and phase: Completed; Phase 3; Phase 2

Conditions: Infertility

Treatments: Drug: Prednisolone and Heparin during COH for IVF; Drug: COH for IVF

Study type: Interventional

Funder types: Other

Identifiers

NCT01590173

123123

Details and patient eligibility

About

The addition of heparin and prednisolone increases pregnancy outcome parameters in women undergoing In Vitro Fertilisation (IVF) with failed IVF cycles.

Enrollment: 86 patients

Sex: Female

Ages: 25 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• personal history of ≥2 failed IVF/ICSI cycles
• age <45 years
• availability of fresh ejaculate sperm for IVF/ICSI procedures
• confirmation of normal uterine cavity
• presence of good quality (Grade I or II) embryos for transfer

Exclusion criteria

• endocrine disorders
• immune disorders
• coagulation disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

86 participants in 2 patient groups

Prednisolone and Heparin during COH for IVF

Experimental group

Treatment:

Drug: Prednisolone and Heparin during COH for IVF

COH for IVF

Active Comparator group

Treatment:

Drug: COH for IVF